Safmannan® the reference yeast postbiotic for animals’ better performance and resilience


Farm animals face multiple stress, including pathogen pressures, high stocking densities, intensive growth, longer production periods, and heat stress. Key questions include how to protect animals against stress and how to improve animals’ production performance under challenging conditions.
The positive effects of Safmannan® have been demonstrated in many species including poultry, farmed fish and pets. The product’s impact has been proven globally through a battery of in vitro and in vivo tests, in cooperation with independent world-class research centres.


Adding Safmannan® to animal diets may help support gastrointestinal balance, preserve gut integrity, and modulate immunity. Safmannan® may help to mitigate the detrimental effects of stress and improve feed efficiency, animal performance, and food safety.

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Safmannan® improves gut function

Increasing the number of beneficial bacteria in the intestinal tract to counteract the colonization by bacterial pathogens such as Salmonella, E. coli, Vibrio spp., and Clostridia is essential. Safmannan® may help to maintain intestinal integrity and defence barriers. Safmannan® balances microbiota, supports gut integrity, and promotes gut function, thus improving feed efficiency, production performance in animals and mitigating the negative effects of stress, such as heat stress.

Safmannan® strengthens animals’ resilience, to limit the use of antibiotics

Pathogen control, gut function preservation, and the enhancement of natural defences contribute to the wellbeing of animals. Safmannan® may help to strengthen animals’ resilience, mitigate negative effects of stress like heat stress in the context of antibiotic reduction.

Safmannan® helps to mitigate Salmonella prevalence and enhance food safety

Salmonella Enteritidis and Salmonella Typhimurium are the most common Salmonella serovars associated with foodborne illnesses in humans. Given the positive effect of Safmannan® on natural defences, microbiota balance and gut function improvement, adding Safmannan® to animal diets may contribute to food safety, early in the food, meat, and egg production chain.

Safmannan® consistent premium quality leads to predictable performance

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Safmannan® is a premium yeast fraction, rich in mannan-oligosaccharides and beta-glucans (1.3 and 1.6). It is obtained from primary culture and the purification of selected Saccharomyces cerevisiae proprietary strain. Fully controlled manufacturing processes and quality certifications ensure that Safmannan® meets the highest standards of ingredients and batch-to-batch consistency, providing significantly better benefits than other commercial yeast cell wall products.


The consistent concentration of mannans (≥ 20%) and beta-glucans (≥ 20%) in the composition of Safmannan®, results in predictable high-performance outcomes.

Mode of action of selected yeast postbiotic Safmannan®

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Safmannan® ensures excellent, repeatable performance, thanks to its 2 active components, mannans and beta-glucans (1.3 and 1.6).


Beta-glucans help modulate the immune system by being in contact with immune cell receptors, triggering them to fight off pathogens.


Mannans may help to mitigate pathogen colonisation in an animal’s intestinal tract by adsorbing and inhibiting the growth of gram-negative bacteria.


Reinforcing the epithelial barrier, and modulating cellular and humoral immunity, contributes to reduce the translocation of bacteria and toxins. Safmannan® may help animals to be more resilient, resulting in excellent performance and welfare.

Your programs with Safmannan

salmo control broilers
Program Heat stress dairy cow
gut health swine
Program Neonate phileo
Meat profit beef cattle

The information provided in this document is to the best of our knowledge, true and accurate. Not all products are available in all regions nor are the associated intended uses and/or claims the same in all regions. Products must only be used in compliance with local laws and regulations and we cannot guarantee freedom for every intended use or country.

Safmannan phileo gut health

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  • 25kg polyethylene bag
  • Big bag 850kg



  • Safmannan® offers high stability with its long shelf life of 2 years



  • Please reach out to our Phileo experts here


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