Safmannan® selected yeast fraction for animals’ better performance and resilience


Farm animals face multiple stress, including pathogen pressures, high stocking densities, intensive growth, longer production periods, and heat stress. Key questions include how to protect animals against stress and how to improve animals’ production performance under challenging conditions.

The positive effects of Safmannan® on pathogen pressure reduction, gut function improvement, and natural defence enhancement, have been demonstrated in many species including poultry, farmed fish and pets. The product’s impact has been proven globally through a battery of in vitro and in vivo tests, in cooperation with independent world-class research centres.


Adding Safmannan® to animal diets has been shown to help decrease the risk of gastrointestinal diseases, preserve gut integrity, and modulate immunity. Safmannan® can help to mitigate the detrimental effects of stress and improve feed efficiency, animal performance, and food safety.

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Safmannan® breaks vicious cycle of gastrointestinal diseases, improving gut function

Preventing colonisation by bacterial pathogens, such as Salmonella, E. coli, Vibrio spp., and Clostridia, and increasing the number of beneficial bacteria in the intestinal tract, Safmannan® helps to decrease the risk of gastrointestinal disease. Furthermore, Safmannan® has been shown to preserve intestinal integrity and defence barriers. Safmannan® balances microbiota, preserves gut integrity, and promotes gut function, thus improving feed efficiency, production performance in animals and mitigating the negative effects of stress, such as heat stress.

Safmannan® strengthens animals’ resilience, reducing the use of antibiotics

Thanks to its positive effect on pathogen pressure reduction, gut function preservation, and the enhancement of natural defences, Safmannan® strengthens the animals’ resilience, mitigates negative effects of stress, like heat stress, thus enabling antibiotic use in animal feeds to be reduced.

Safmannan® decreases Salmonella prevalence enhancing food safety

Safmannan® consistently helps lower the prevalence of Salmonella serovars that are most commonly associated with foodborne illnesses in humans, such as Salmonella Enteritidis and Salmonella Typhimurium. Given the positive effect of Safmannan® on natural defence enhancement, pathogen pressure reduction and gut function improvement, adding Safmannan® to animal diets contributes to food safety, early in the food, meat, and egg production chain.

Safmannan® consistent premium quality leads to predictable performance

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Safmannan® is a premium yeast fraction, rich in mannan-oligosaccharides and beta-glucans (1.3 and 1.6). It is obtained from primary culture and the purification of selected Saccharomyces cerevisiae proprietary strains. Fully controlled manufacturing processes and quality certifications ensure that Safmannan® meets the highest standards of ingredients and batch-to-batch consistency, providing significantly better benefits than other commercial yeast cell wall products.


The consistent concentration of mannans (≥ 20%) and beta-glucans (≥ 20%) in the composition of Safmannan®, results in predictable high-performance outcomes.

Mode of action of selected yeast fraction Safmannan®

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Safmannan® ensures excellent, repeatable performance, thanks to its 2 active components, mannans and beta-glucans (1.3 and 1.6).


Beta-glucans stimulate the immune system by being in contact with immune cell receptors, triggering them to fight off pathogens.


Mannans help diminish pathogen colonisation in an animal’s intestinal tract by adsorbing gram-negative pathogens.


Reducing the translocation of bacterial products, reinforcing the epithelial barrier, and modulating cellular and humoral immunity, Safmannan® helps animals be more resilient, resulting in excellent performance.

Your programs with Safmannan

salmo control broilers
Program Heat stress dairy cow
gut health swine
Program Neonate phileo
Meat profit beef cattle
Safmannan phileo gut health

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  • 25kg polyethylene bag
  • Big bag 850kg



  • Safmannan® offers high stability with its long shelf life of 2 years



  • Please reach out to our Phileo experts here

Not all products are available in all markets nor associated claims allowed in all regions. The information provided in this document is to the best of our knowledge, true and accurate. However, products must only be used in compliance with local laws and regulations and we cannot guarantee freedom of use for every intended application or country.

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