{"id":396372,"date":"2020-06-24T14:48:41","date_gmt":"2020-06-24T12:48:41","guid":{"rendered":"https:\/\/demo14.lesaffre.misyl.net\/?page_id=396372"},"modified":"2023-09-13T11:22:11","modified_gmt":"2023-09-13T09:22:11","slug":"immune-modulation-antibody-titers","status":"publish","type":"page","link":"https:\/\/phileo-lesaffre.com\/en\/broilers\/immune-modulation-antibody-titers\/","title":{"rendered":"Broilers Immune modulation and antibody titers"},"content":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” el_class=”breadcrumbtxt” z_index=””][vc_column][vc_column_text]Phileo by Lesaffre<\/a><\/span><\/span><\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_column_text]<\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5% 8% 5% 0%”][vc_column_text]<\/p>\n

Immune modulation and antibody titers<\/span><\/h1>\n

[\/vc_column_text][vc_single_image image=”385″ img_size=”65×33″ qode_css_animation=”” css=”.vc_custom_1590613047306{padding-top: 5% !important;padding-bottom: 5% !important;}”][vc_column_text css=”.vc_custom_1610544940448{padding-right: 8% !important;}”]Disease prevention demands a global approach to understanding pathogen contamination and the application of on-farm cleaning and disinfection procedures. Biosecurity is vital.<\/p>\n

 <\/p>\n

All the stresses that make birds more sensitive to disease must be controlled by good farm management. Phileo by Lesaffre has developed solutions that complement existing controls, making birds more resistant to disease.<\/p>\n

 <\/p>\n

Safmannan<\/a>\u00ae<\/sup>, a premium yeast parietal fraction, rich in mannans and beta-glucans 1.3 and 1.6, helps maintain good gut integrity, preventing pathogenic bacteria contamination (such as E.coli<\/em>, Salmonella<\/em> and Clostridium<\/em>). It also helps improve immune system functioning and the birds\u2019 response to vaccines.[\/vc_column_text][vc_single_image image=”396256″ img_size=”120×178″ alignment=”right” qode_css_animation=””][\/qode_elements_holder_item][qode_elements_holder_item cover=”yes” vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” background_image=”397730″][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item cover=”yes” advanced_animations=”no” background_image=”397706″][\/qode_elements_holder_item][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5% 2% 5% 10%” background_color=”#e58734″][vc_column_text]<\/p>\n

Raising the barriers of the innate immune system<\/span><\/h2>\n

[\/vc_column_text][vc_single_image image=”27″ img_size=”50×25″ qode_css_animation=”” css=”.vc_custom_1592227932921{padding-top: 5% !important;padding-bottom: 5% !important;}”][vc_column_text css=”.vc_custom_1593163068293{padding-right: 10% !important;}”]It is possible to help the adaptive immune system to be more efficacious after a vaccination. This specific reaction is associated with a non-specific one, called the innate immunity.<\/span><\/p>\n

 <\/p>\n

The first defence line is composed of physical barriers (skin, epithelium, tight junction, mucus on epithelial cells, trachea cilia flutter, gut peristalsis), chemical barriers (fatty acids, lysozyme, proventricular pH acidity, antibacterial peptides), and microbiologic barriers.<\/span><\/p>\n

 <\/p>\n

The second defence line is composed of phagocytes, able to eliminate bacteria opsonized by the complement system, and mast cells, able to \u2018wake up\u2019 the immune system when there is an infection. Finally it is composed of natural killer cells, able to kill directly virus infected cells or tumour cells.<\/span>[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” css=”.vc_custom_1592234497567{background-color: #ffffff !important;}” z_index=””][vc_column][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5% 10% 5% 5%” background_color=”#706f6f”][vc_column_text]<\/p>\n

Preserving good gut integrity<\/span><\/h2>\n

[\/vc_column_text][vc_single_image image=”27″ img_size=”50×25″ qode_css_animation=”” css=”.vc_custom_1592232787710{padding-top: 5% !important;padding-bottom: 5% !important;}”][vc_column_text]As 70% of the bird immune system capacity is located in the digestive tract, it is important to preserve good gut integrity. The chronic intestinal inflammation, due to the high feed intake of modern poultry breeds, has to be controlled. Safmannan can help the innate immune system to be better prepared against an infection. This is done via the following mode of actions:<\/span><\/p>\n

 <\/p>\n

\u2022 Pathogen binding
\n\u2022 Increased goblet cells number
\n\u2022 Modulation of inflammation
\n<\/span>[\/vc_column_text][\/qode_elements_holder_item][qode_elements_holder_item cover=”yes” advanced_animations=”no” background_image=”396525″][vc_separator type=”transparent” up=”200″ down=”200″][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item advanced_animations=”no”][vc_single_image image=”403938″ img_size=”full” onclick=”link_image” qode_css_animation=”” qode_hover_animation=”zoom_in”][\/qode_elements_holder_item][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5% 2% 5% 10%” background_color=”#e58734″][vc_column_text]<\/p>\n

Effects of Safmannan\u00ae<\/sup> on immune system modulation<\/span><\/h2>\n

[\/vc_column_text][vc_single_image image=”27″ img_size=”50×25″ qode_css_animation=”” css=”.vc_custom_1592232787710{padding-top: 5% !important;padding-bottom: 5% !important;}”][vc_column_text]Several R&D farm trials prove these effects, following various different vaccinations, such as Newcastle Disease (ND) or Avian Influenza (H5 or H9). In this trial, broilers were vaccinated at 10 days old with a live ND vaccine and fed with either a feed supplemented with Safmannan<\/a>\u00ae<\/sup> or a control feed. Blood samples were taken 1 week and 2 weeks after vaccination and analysed by HI-test. Two weeks after vaccination, the vaccine response in the Safmannan<\/a>\u00ae<\/sup> supplemented group was significantly higher than in the control group.<\/span>[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5% 2% 5% 10%” background_color=”#706f6f”][vc_column_text]<\/p>\n

Effects of yeast beta-glucan\u00a0on trained immunity<\/span><\/h2>\n

[\/vc_column_text][vc_single_image image=”27″ img_size=”50×25″ qode_css_animation=”” css=”.vc_custom_1592232787710{padding-top: 5% !important;padding-bottom: 5% !important;}”][vc_column_text]Phileo by Lesaffre has also developed yeast beta-glucan product, in which beta-glucans 1.3 and 1.6 are purified and separated from the mannans fraction, reaching more than 50% of the composition of the product. Its activity is targeted on the immune system, while Safmannan<\/a>\u00ae<\/sup> has a broader effect.
\nSeveral in vivo<\/em> trials have proved the beneficial effect of yeast beta-glucans\u00a0in improving vaccine response.<\/span><\/p>\n

 <\/p>\n


\nIn this trial, beta-glucans were\u00a0used at 125g\/T to show its effect after a vaccination against ND with an inactivated vaccine, injected at 12 and 24 days old. The vaccine response is faster and stronger compared to a vaccinated control group.<\/span>[\/vc_column_text][\/qode_elements_holder_item][qode_elements_holder_item advanced_animations=”no”][vc_single_image image=”414362″ img_size=”full” onclick=”link_image” qode_css_animation=”” qode_hover_animation=”zoom_in”][\/qode_elements_holder_item][\/qode_elements_holder][vc_separator type=”transparent”][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”yes” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_separator type=”transparent” up=”10″ down=”10″][vc_column_text css=”.vc_custom_1593402547571{padding-top: 2% !important;padding-bottom: 2% !important;}”]<\/p>\n

Find out more about broiler management<\/span><\/h2>\n

[\/vc_column_text][vc_separator type=”transparent” up=”5″ down=”5″][\/vc_column][vc_column width=”1\/5″][vc_single_image image=”396605″ img_size=”full” alignment=”center” onclick=”custom_link” qode_css_animation=”” qode_hover_animation=”zoom_in” css=”.vc_custom_1593403060374{padding-top: 5% !important;padding-bottom: 5% !important;}” link=”\/en\/broilers\/managing-gut-health-broilers\/”][\/vc_column][vc_column width=”1\/5″][vc_single_image image=”396604″ img_size=”full” alignment=”center” onclick=”custom_link” qode_css_animation=”” qode_hover_animation=”zoom_in” css=”.vc_custom_1593403099308{padding-top: 5% !important;padding-bottom: 5% !important;}” link=”\/en\/broilers\/atb-reduction-broilers\/”][\/vc_column][vc_column width=”1\/5″][vc_single_image image=”396609″ img_size=”full” alignment=”center” onclick=”custom_link” qode_css_animation=”” qode_hover_animation=”zoom_in” css=”.vc_custom_1593403128035{padding-top: 5% !important;padding-bottom: 5% !important;}” link=”\/en\/broilers\/pathogen-control-in-broilers\/”][\/vc_column][vc_column width=”1\/5″][vc_single_image image=”396608″ img_size=”full” alignment=”center” onclick=”custom_link” qode_css_animation=”” qode_hover_animation=”zoom_in” css=”.vc_custom_1593403196562{padding-top: 5% !important;padding-bottom: 5% !important;}” link=”\/en\/broilers\/broilers-oxidative-stress\/”][\/vc_column][vc_column width=”1\/5″][vc_single_image image=”396606″ img_size=”full” alignment=”center” onclick=”custom_link” qode_css_animation=”” qode_hover_animation=”zoom_in” css=”.vc_custom_1593403220228{padding-top: 5% !important;padding-bottom: 5% !important;}” link=”\/en\/broilers\/broilers-heat-stress\/”][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” el_class=”breadcrumbtxt” z_index=””][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_column_text] [\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5% 8% 5% 0%”][vc_column_text] Immune modulation and antibody titers [\/vc_column_text][vc_single_image image=”385″ img_size=”65×33″ qode_css_animation=”” css=”.vc_custom_1590613047306{padding-top: 5% !important;padding-bottom:…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":236,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full_width.php","meta":{"footnotes":""},"class_list":["post-396372","page","type-page","status-publish","hentry"],"yoast_head":"\nImprove broilers Immune System Modulation | Phileo by Lesaffre<\/title>\n<meta name=\"description\" content=\"Discover our solutions that complement existing controls about good farm management, making birds more resistant to disease\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/phileo-lesaffre.com\/en\/broilers\/immune-modulation-antibody-titers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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